Trifluoroacetic Anhydride

CAS# 407-25-0

Product Description

Trifluoroacetic anhydride (TFAA) is a versatile chemical reagent used in various industrial applications.

Product:

Trifluoroacetic Anhydride

CAS:

407-25-0

Synonym:

Perfluoroacetic anhydride; Trifluoroacetic acid anhydride

Structure:

Typical Characteristics

Appearance

Colorless liquid

Boiling point

39.5-40 °C

Density

1.511 g/cm3

Melting point

−65 °C

Molecular Weight

210.03

Odor

Pungent odor

Purity

≥99%

Refractive index

1.3

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We Offer Trifluoroacetic Anhydride
in various grades

A few of the grades available are listed below:

Trifluoroacetic Anhydride used in many
industry applications

Trifluoroacetic anhydride (TFAA) is a versatile chemical reagent used in various industrial applications. Here are some of its key uses:

  1. Organic Synthesis: TFAA is commonly used as an acylating agent in organic synthesis, facilitating the introduction of trifluoroacetyl groups into organic molecules.
  2. Pharmaceutical Industry: It is utilized in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs), particularly for introducing trifluoromethyl groups, which can enhance the biological activity and stability of drug molecules.
  3. Peptide Synthesis: TFAA is used in the protection and deprotection of amino groups during peptide synthesis, improving the efficiency and yield of peptide production.
  4. Analytical Chemistry: In analytical chemistry, TFAA is employed in the derivatization of compounds to enhance their detection and analysis by various techniques, such as gas chromatography (GC) and mass spectrometry (MS).
  5. Polymer Chemistry: TFAA is used in the modification of polymers, introducing trifluoroacetyl groups to improve their chemical resistance, thermal stability, and other desirable properties.
  6. Chemical Manufacturing: It serves as a reagent in the production of agrochemicals, dyes, and other fine chemicals, aiding in the synthesis of complex organic molecules.
  7. Materials Science: TFAA is utilized in the preparation of advanced materials, such as fluorinated polymers and coatings, which benefit from the unique properties imparted by the trifluoroacetyl group.
  8. Biotechnology: In biotechnology, TFAA is used for protein modification and labeling, facilitating the study of protein structure and function.
  9. Environmental Analysis: TFAA is employed in environmental analysis to derivatize and detect trace amounts of pollutants and contaminants, improving analytical sensitivity and accuracy.
  10. Laboratory Reagent: TFAA is a valuable reagent in research and development laboratories for developing new synthetic methodologies and exploring chemical reactions involving trifluoroacetylation.