Chloroquine
Product Description
Chloroquine, a drug historically used primarily for the prevention and treatment of malaria, has found applications in various other medical and research areas due to its pharmacological properties.
Product:
Chloroquine
CAS:
54-05-7
Synonym:
Aralen; Chlorochin; 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
Structure:
Typical Characteristics
Appearance
Colorless crystals
Density
1.050 g/cm3
Melting point
87 °C
Molecular Weight
319.87
Odor
Odorless
Purity
99%
Refractive index
1.6010
Uses, Applications & Markets
Key applications
Markets
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Chloroquine used in many
industry applications
Chloroquine, a drug historically used primarily for the prevention and treatment of malaria, has found applications in various other medical and research areas due to its pharmacological properties. Here's a look at some of its uses:
- Antimalarial: Chloroquine is most well-known for its role in preventing and treating malaria caused by Plasmodium parasites. It works by inhibiting the parasite's ability to break down and digest hemoglobin.
- Anti-inflammatory: Due to its mild immunosuppressive and anti-inflammatory effects, chloroquine is used in the treatment of autoimmune diseases such as rheumatoid arthritis and lupus erythematosus.
- Antiviral Research: It has been explored as a potential antiviral agent against viruses like HIV, coronavirus, and influenza, though its effectiveness varies and is subject to ongoing research and clinical trials.
- Amoebiasis: Outside of malaria, chloroquine has been used to treat extraintestinal amoebiasis, an infection caused by amoebae spreading to organs outside the intestines, like the liver.
- Oncology Research: There is ongoing research into chloroquine's potential use in cancer therapy, particularly in its ability to inhibit autophagy, a process that cancer cells can exploit to survive under stress conditions.
- Photoprotection: Chloroquine has been used in treatment protocols for photodermatoses, offering protection against the harmful effects of sunlight in sensitive individuals.
- Research Tool: In scientific research, chloroquine is used to inhibit lysosomal autophagy in cultured cells, aiding in the study of cellular processes and disease mechanisms.